|
Symbol Name ID |
Slc18a2
solute carrier family 18 (vesicular monoamine), member 2 MGI:106677 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Hyposmia |
Spasticity |
Ataxia |
Dysdiadochokinesis |
Incoordination |
Bradykinesia |
Parkinsonism |
Tremor |
Dysarthria |
Depression |
Anxiety |
Panic attack |
Hallucinations |
Apathy |
Reduced social reciprocity |
Impulsivity |
Agitation |
Restless legs |
Cognitive impairment |
Dementia |
Frontal lobe dementia |
Short attention span |
Intellectual disability, mild |
Sleep abnormality |
Insomnia |
Hyperreflexia |
Dyskinesia |
Dystonia |
Oculogyric crisis |
Gait imbalance |
Shuffling gait |
Postural instability |
Stooped posture |
Global developmental delay |
Delayed ability to sit |
Delayed ability to walk |
Abnormal autonomic nervous system physiology |
| Disease(s) Associated with SLC18A2 | |||||||||||||||||||||||||||||||||||||
| infantile parkinsonism-dystonia 2 | |||||||||||||||||||||||||||||||||||||
| Parkinson's disease |
| Mouse Phenotypes | nervous system phenotype |
increased susceptibility to dopaminergic neuron neurotoxicity |
abnormal dopaminergic neuron morphology |
decreased dopaminergic neuron number |
abnormal synaptic vesicle morphology |
neuron degeneration |
alpha-synuclein inclusion body |
abnormal nervous system physiology |
enhanced long-term potentiation |
abnormal neurotransmitter secretion |
abnormal neurotransmitter uptake |
abnormal synaptic neurotransmitter level |
|
| Availability | Mouse Genotype | ||||||||||||
| Slc18a2tm1Edw/Slc18a2tm1Edw | |||||||||||||
| Slc18a2tm1Mca/Slc18a2tm1Mca | |||||||||||||
| Slc18a2tm2Kmo/Slc18a2tm2Kmo | |||||||||||||
| Slc18a2tm1Mca/Slc18a2+ | |||||||||||||
| Slc18a2tm1Uhl/Slc18a2+ | |||||||||||||
| Slc18a2tm1.1Bgir/Slc18a2tm1.1Bgir Slc6a4tm1(cre)Xz/Slc6a4+ (conditional) |
* | ||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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